Yan (2017) [25] |
Experimental (n = 13) |
Acupuncture (BL2, Ex-HN10 etc.) |
Palpebal fissure width Angle of view 4th level: Excellent, Good, fair, poor |
Palpebal fissure width: 3.11 ± 1.23→8.33 ± 1.31 |
Palpebal fissure width p < 0.05 |
Angle of view: 68.92 ± 22.31→16.23 ± 13.21 |
Control (n = 13) |
4th level: Excellent (n = 10), Good (n = 3), Fair (n = 0), Poor (n = 0) |
Angle of view p < 0.05 |
Male (n = 15) |
Insulin, Vitamin B SC injection. |
Palpebal fissure width 3.20 ± 1.20→5.21 ± 1.22 |
Total efficiency: 100% p < 0.01 |
Female (n = 11) |
Angle of view 67.82 ± 23.73→38.21 ± 14.33 |
4th level: Excellent (n = 4), Good (n = 7), Fair (n = 2), Poor (n = 11) |
Zou (2018) [26] |
Experimental (n = 25) |
Acupuncture (BL1, GB14, GB1, Ex-HN10, ST2, TE23, ST1) |
Palpebal fissure width Eye Movement 3rd level: Excellent, Good, Poor |
Palpebal fissure width: 6.05 ± 0.43 |
Palpebal fissure width p < 0.05 |
Male (n = 11) |
Eye Movement: 4.54 ± 0.41 |
Female (n = 14) |
3rd level: Excellent (n = 13), Good (n = 11), Poor (n = 1) |
Eye movement p < 0.05 |
Control (n = 25) |
Acupuncture (Traditional acupoints) |
Palpebal fissure width:4.33 ± 0.30 |
Total efficiency: 96% p < 0.05 |
Male (n = 13) |
Eye Movement: 3.54 ± 0.32 |
Female (n = 12) |
3rd level: Excellent (n = 8), Good (n = 10), Poor (n = 7) |
Li (2017) [27] |
Experimental (n = 30) |
Acupuncture (BL1, Ex-HN4, Ex-HN10, Ex-HN7, GB20, LI4, ST36, TE23, ST1, GV20), Herb medication |
3rd level: Excellent, Good, Poor Quality of life score |
3rd level: Excellent (n = 20), Good (n = 8), Poor (n = 2) |
Total efficiency: 93.3% p =0.016 |
Male (n = 20) |
Quality of life score 55.70 ± 4.52→76.88 ± 8.65 |
Female (n = 10) |
Control (n = 30) |
Western Medication |
3rd level: Excellent (n = 15), Good (n = 5), Poor (n = 10) |
Quality of life score p =0.000 |
Male (n = 18) |
Quality of life score 55.63 ± 4.81→67.29 ± 8.30 |
Female (n = 12) |
Sun (2015) [28] |
Experimental (n = 32) |
Acupuncture (BL1, ST1, GB1, LI20, BL2, ST2, GV20, GB20, KI3, SP3, LR3, SP6, GB20) |
Palpebral fissure width Size of pupil VAS: Diplopsia 3rd level: Excellent, Good, Poor |
Palpebral fissure width 4.82 ± 1.03→3.27 ± 0.51 |
Palpebral fissure width p < 0.05 |
Male (n = 16) |
Size of pupil 2.79 ± 0.64→7.26 ± 0.43 |
Female (n = 13) |
VAS: Diplopsia 4.55 ± 1.33→2.35 ± 0.98 |
3rd level: Excellent (n = 20), Good (n = 8), Poor (n = 2) |
Size of pupil p < 0.05 |
Control (n = 29) |
Acupuncture (Group 1 BL20, BL23, ST36, SP6, GB14 / Gruop2 BL20, CV6, ST36, GB14 / Group 3 ST36, LR3, SP6, GB20, GB14 / Group 4 GB14, BL2, GB20, BL17) |
Palpebral fissure width 4.66 ± 0.92→3.96 ± 0.58 |
VAS: Diplopsia p < 0.05 |
Male (n = 18) |
Size of pupil 2.70 ± 0.62→5.09 ± 0.41 |
Total efficiency: 93.75% p > 0.05 |
Female (n = 14) |
VAS: Diplopsia 4.51 ± 1.27→3.68 ± 1.07 |
3rd level: Excellent (n = 20), Good (n = 8), Poor (n = 2) |
Yu (2015) [29] |
Experimental (n = 43) |
Acupuncture (GV26, PC6, SP6, GV23, Ex-HN3, GB12, LI4, GB20, BL10, Ex-HN5, BL1, Ex-HN7, ST3, ST2 etc.), Western medication |
3rd level: Excellent, Good, Poor |
3rd level: Excellent (n = 19), Good (n = 10), Poor (n = 11) |
Total efficiency: 93.02% p < 0.05 |
Male (n = 24) |
Female (n = 19) |
Control (n = 43) |
Acupuncture (GV26, PC6, SP6, Ex-HN3, GV23, GV20, GB12, GB20, BL10, ST2, Ex-HN5, Ex-HN4, Ex-HN7), Western medication |
3rd level: Excellent (n = 14), Good (n = 12), Poor (n = 10) |
Male (n = 25) |
Female (n = 18) |
Pan (2015) [30] |
Experimental (n = 46) |
Acupuncture (BL1, Ex-HN4, Ex-HN10, Ex-HN7, ST2, GB20, GV26, SP6), Herb medication, Western medication |
4th level: Excellent, Good, fair, poor VAS: Ptosis, Size of pupil, Eye Movement, Diplopsia |
4th level: Excellent (n = 13), Good (n = 19), Fair (n = 13), Poor (n = 10) |
Total efficiency: 93.48% p < 0.05 |
Male (n = 30) |
Ptosis 2.68 ± 0.55→7.11 ± 0.46 |
Female (n = 16) |
Size of pupil 4.53 ± 0.32→3.56 ± 0.25 |
|
Eye Movement 2.36 ± 0.76→0.78 ± 0.56 |
Ptosis p < 0.05 |
|
Diplopsia 4.42 ± 1.02→2.35 ± 0.56 |
Size of pupil p < 0.05 |
Control (n = 46) |
Western medication |
4th level: Excellent (n = 8), Good (n = 15), Fair (n = 13), Poor (n = 10) |
Eye Movement p < 0.05 |
Male (n = 30) |
Ptosis 2.67 ± 0.57→5.63 ± 0.38 |
Diplopsia p < 0.05 |
Female (n = 16) |
Size of pupil 4.52 ± 0.35→3.89 ± 0.31 |
|
Eye Movement 2.34 ± 0.78→1.34 ± 0.95 |
|
Diplopsia 4.45 ± 1.05→3.43 ± 0.89 |
Wang (2014) [31] |
Experimental (n = 55) |
Acupuncture (BL1, Ex-HN4, Ex-HN10, ST2, GB20, LI4, ST36, TE23, ST1, GV20, Ashi) |
3rd level: Excellent, Good, Poor light reflex Diopter Palpebral fissure width |
3rd level: Excellent (n = 29), Good (n = 18), Poor (n = 8) |
Total efficiency: 85.5% p < 0.05 |
Male (n = 29) |
Light reflex 4.28 ± 0.84→3.41 ± 0.64 |
Female (n = 26) |
Diopter 53.76 ± 9.73→98.56 ± 10.39 |
|
Palpebral fissure width 2.72 ± 0.56→6.95 ± 0.79 |
Light reflex p < 0.05 |
Control (n = 55) |
Rehabilitation treatment |
3rd level: Excellent (n = 21), Good (n = 15), Poor (n = 19) |
Diopter p < 0.05 |
Male (n = 27) |
Light reflex 4.34 ± 0.90→3.79 ± 0.73 |
Ocular width p < 0.05 |
Female (n = 28) |
Diopter 52.04 ± 11.23→92.23 ± 12.12 |
|
Palpebral fissure width 2.63 ± 0.71→6.58 ± 0.64 |
Chen (2014) [32] |
Experimental (n = 20) |
Acupuncture (BL1, BL2, GB14, GB1, LI4, ST36, SP6, ST1, LR3, GB37, SP3) |
3rd level: Excellent, Good, Poor Diplopsia Palpebral fissure width |
3rd level: Excellent (n = 3), Good (n = 16), Poor (n = 1) |
Total efficiency: 95.0% p < 0.05 |
Male (n = 13) |
Diplopsia 4.25 ± 1.12→3.58 ± 1.25 |
Female (n = 7) |
Palpebral fissure width 2.54 ± 0.31→6.47 ± 0.19 |
Diplopsia p < 0.05 |
Control (n = 20) |
Western medication |
3rd level: Excellent (n = 1), Good (n = 13), Poor (n = 6) |
Palpebral fissure width p < 0.05 |
Male (n = 11) |
Diplopsia 4.53 ± 1.27→2.67 ± 1.03 |
Female (n = 9) |
Palpebral fissure width 2.44 ± 0.28→6.68 ± 0.21 |
Chen (2013) [33] |
Experimental (n = 29) |
XNKQ Acupuncture (BL1, Ex-HN4, Ex-HN10, Ex-HN7, ST2, GB20, GV26, SP6, GV20, Ex-HN3, GV23, PC6, GB12, BL10) |
4th level: Excellent, Good, fair, poor Palpebral fissure width Size of pupil |
4th level: Excellent (n = 21), Good (n = 5), Fair (n = 2), Poor (n = 1) |
Total efficiency: 96.55% p < 0.05 |
Male (n = 16) |
Palpebral fissure width 2.66 ± 0.52→7.15 ± 0.43 |
Female (n = 13) |
Size of pupil 4.58 ± 0.42→3.61 ± 0.34 |
Palpebral fissure width p < 0.05 |
Control (n = 26) |
Acupuncture (BL1, Ex-HN4, Ex-HN10, Ex-HN7, ST2, GB20, LI4, GV26, SP6, GV20, Ex-HN3, GV23, PC6, GB12, BL10) |
4th level: Excellent (n = 9), Good (n = 7), Fair (n = 4), Poor (n = 6) |
Size of pupil p < 0.05 |
Male (n = 15) |
Palpebral fissure width 2.71 ± 0.65→5.84 ± 0.47 |
Female (n = 11) |
Size of pupil 4.51 ± 0.36→3.96 ± 0.32 |
Yang (2012) [34] |
Experimental (n = 74) |
Acupuncture (BL2, GB14, Ex-HN4, GB1, ST2, LI4, ST36, TE23, SP6, LR3, BL11, CV12, ST40, KI6, GB43, Scalp), Western medication |
4th level: Excellent, Good, fair, poor |
4th level: Excellent (n = 45), Good (n = 15), Fair (n = 6), Poor (n = 8) |
Total efficiency: 89.2% p < 0.05 |
Male (n = 42) |
Female (n = 32) |
Control (n = 58) |
Western medication |
4th level: Excellent (n = 20), Good (n = 13), Fair (n = 3), Poor (n = 22) |
Male (n = 30) |
Female (n = 28) |
Liu (2008) [35] |
Experimental (n = 24) |
Acupuncture (BL1, Ex-HN10, ST36, TE23, SP6, LR3, GV20, ST40), Western medication |
3rd level: Excellent, Good, Poor |
3rd level: Excellent (n = 15), Good (n = 8), Poor (n = 1) |
Total efficiency: 95.8% p < 0.05 |
Male (n = 13) |
Female (n = 11) |
Control (n = 24) |
Western medication |
3rd level: Excellent (n = 9), Good (n = 8), Poor (n = 7) |
Male (n = 14) |
Female (n = 10) |
Liu (2013) [36] |
Experimental (n = 30) |
Acupuncture (BL1, ST1, Ashi) |
3rd level: Excellent, Good, Poor Palpebral fissure width |
3rd level: Excellent (n = 7), Good (n = 19), Poor (n = 4) |
Total efficiency: 86.7% p < 0.05 |
Male (n = 17) |
Palpebral fissure width 0.80 ± 0.76→5.67 ± 2.70 |
Female (n = 13) |
Control (n = 30) |
Western medication |
3rd level: Excellent (n = 9), Good (n = 8), Poor (n = 7) |
Palpebral fissure width p < 0.05 |
Male (n = 18) |
Palpebral fissure width 0.88 ± 0.72→4.27 ± 2.01 |
Female (n = 12) |
Yang (2017) [37] |
Experimental (n = 30) |
Acupuncture (ST1, BL1, Ex-HN4, GB1, BL2, Ex-HN3, GB14, ST2, GB20, GV23, LI4, LR3) |
3rd level: Excellent, Good, Poor VAS: Diplopsia Size of pupil Palpebral fissure width |
3rd level: Excellent (n = 17), Good (n = 12), Poor (n = 1) |
Total efficiency: 96.67% p < 0.01 |
Male (n = 16) |
Diplopsia 4.73 ± 0.980→1.33 ± 0.959 |
Female (n = 14) |
Size of pupil 3.350 ± 0.2862→3.180 ± 0.4080 |
|
Palpebral fissure width 4.833 ± 0.5213→9.560 ± 0.5399 |
Diplopsia p < 0.05 |
Control (n = 30) |
Acupuncture (GB14, BL2, Ex-HN4, TE23, BL60, Ashi) |
3rd level: Excellent (n = 10), Good (n = 13), Poor (n = 7) |
Size of pupil p < 0.01 |
Male (n = 13) |
Diplopsia 5.07 ± 0.015→1.93 ± 0.640 |
Palpebral fissure width p < 0.01 |
Female (n = 17) |
Size of pupil 5.300 ± 0.3206→3.710 ± 0.3898 |
|
Palpebral fissure width 4.860 ± 0.5449→8.323 ± 0.5380 |
Yang (2017) [38] |
Experimental (n = 20) |
Acupuncture (BL1, BL2, Ex-HN4, GB1, Ex-HN10, LI4, ST36, TE23), Western medication |
3rd level: Excellent, Good, Poor VAS: Diplopsia Palpebral fissure width |
3rd level: Excellent (n = 11), Good (n = 8), Poor (n = 1) |
Total efficiency: 95.0% p < 0.05 |
Male (n = 12) |
Diplopsia 4.30 ± 1.49→1.20 ± 1.64 |
Female (n = 8) |
Size of pupil 5.35 ± 1.04→3.45 ± 0.60 |
|
Palpebral fissure width 4.85 ± 1.39→7.55 ± 1.19 |
Diplopsia p < 0.05 |
Control (n = 20) |
Western medication |
3rd level: Excellent (n = 7), Good (n = 9), Poor (n = 4) |
Palpebral fissure width p < 0.05 |
Male (n = 12) |
Diplopsia 4.70 ± 1.17→2.60 ± 2.16 |
Female (n = 8) |
Size of pupil 5.15 ± 0.88→3.95 ± 0.89 |
|
Palpebral fissure width 4.35 ± 0.81→6.45 ± 1.32 |
Dong (2012) [39] |
Experimental (n = 30) |
Acupuncture (Upper eye point 1, 2, 3, Lower eye point 1,2) |
3rd level: Excellent, Good, Poor VAS: Diplopsia Size of pupil Palpebral fissure width |
3rd level: Excellent (n = 18), Good (n = 10), Poor (n = 2) |
Total efficiency: 93.3% p < 0.05 |
Male (n = 16) |
Diplopsia 4.41 ± 1.11→1.00 ± 1.48 |
Female (n = 14) |
Size of pupil 5.39 ± 0.49→3.13 ± 0.57 |
|
Palpebral fissure width 4.72 ± 1.59→9.24 ± 1.80 |
Diplopsia p < 0.05 |
Control (n = 30) |
Acupuncture (GB14, Ex-HN4, BL2, BL1, TE23) |
3rd level: Excellent (n = 10), Good (n = 14), Poor (n = 6) |
Size of pupil p < 0.05 |
Male (n = 17) |
Diplopsia 4.45 ± 0.89→1.87 ± 1.66 |
Palpebral fissure width p < 0.05 |
Female (n = 13) |
Size of pupil 5.21 ± 0.51→3.65 ± 0.76 |
|
Palpebral fissure width 4.58 ± 1.43→8.30 ± 1.92 |
Guo (2013) [41] |
Experimental (n = 20) |
Pharmacopuncture (BL1, GB14, GB1, Ex-HN10, ST2, GB20) |
4th level: Excellent, Good, fair, poor Eyeball movement degree Palpebral fissure width Size of pupil |
4th level: Excellent (n = 46), Good (n = 82), Fair (n = 81), Poor (n = 19) |
Total efficiency: 91.7% p < 0.05 |
Male (n = 13) |
Eyeball movement degree |
Female (n = 7) |
Musculus rectus medialis 8.0 ± 1.4→20.6 ± 1.2 |
|
Superior rectus muscle 2.2 ± 0.5→4.4 ± 0.5 |
|
Musculus rectus inferior 2.3 ± 0.4→4.8 ± 0.3 |
|
Infer oblique muscle 3.9 ± 0.2→4.7 ± 0.3 |
|
Palpebral fissure width 2.2 ± 0.5→6.8 ± 0.2 |
|
Size of pupil 4.5 ± 0.3→3.4 ± 0.3 |
Eyeball movement degree |
Control (n = 20) |
Western medication |
4th level: Excellent (n = 25), Good (n = 75), Fair (n = 68), Poor (n = 60) |
Musculuc rectus medialis p < 0.05 |
Male (n = 11) |
Eyeball movement degree |
Palpebral fissure width p < 0.05 |
Female (n = 9) |
Musculus rectus medialis 8.1 ± 1.3→17.1 ± 1.1 |
|
Superior rectus muscle 2.4 ± 0.6→4.3 ± 0.4 |
|
Musculus rectus inferior 2.6 ± 0.2→4.1 ± 0.3 |
|
Infer oblique muscle 4.0 ± 0.1→4.5 ± 0.6 |
|
Palpebral fissure width 2.3 ± 0.6→4.9 ± 0.4 |
|
Size of pupil 4.6 ± 0.4→3.4 ± 0.2 |
Song (2013) [40] |
Experimental (n = 24) |
Fire-needle therapy (GB14, BL2, Ex-HN4, TE23, Ex-HN5, ST2, ST36) |
3rd level: Excellent, Good, Poor |
3rd level: Excellent (n = 15), Good (n = 8), Poor (n = 1) |
Total efficiency: 95.8% p < 0.05 |
Male (n = 21) |
Female (n = 3) |
Control (n = 24) |
Acupuncture (BL20, BL18, BL23, ST36, GB37, GB20, GB14, BL2, TE23, Ex-HN5, ST2) |
3rd level: Excellent (n = 10), Good (n = 7), Poor (n = 7) |
Male (n = 19) |
Female (n = 5) |
Zhan (2012) [42] |
Group 1 (n = 24) |
Electroacupuncture (BL1, BL2, GB14, Ex-HN4, ST2, ST36, TE23, SP6, ST1, SP10) |
3rd level: Excellent, Good, Poor |
Efficiency 3rd level: Excellent (n = 12), Good (n = 8), Poor (n = 4) |
Total efficiency: |
Male (n = 10) |
Diopter 3rd level: Excellent (n = 12), Good (n = 9), Poor (n = 3) |
Female (n = 14) |
Group 1 83.30% |
Group 2 (n = 23) |
Rehabilitation treatment |
Efficiency 3rd level: Excellent (n = 5), Good (n = 7), Poor (n = 11) |
Group 3 96.00% p < 0.05 |
Male (n = 12) |
Diopter 3rd level: Excellent (n = 5), Good (n = 8), Poor (n = 10) |
Diopter efficiency: |
Female (n = 11) |
Group 1 85.20% |
Group 3 (n = 25) |
Electroacupuncture, Rehabilitation treatment |
Efficiency 3rd level: Excellent (n = 21), Good (n = 3), Poor (n = 1) |
Group 3 96.00% p < 0.05 |
Male (n = 16) |
Diopter 3rd level: Excellent (n = 21), Good (n = 3), Poor (n = 1) |
Female (n = 9) |