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J Acupunct Res > Volume 33(2); 2016 > Article
Cha, Lee, Lee, Song, and Kim: A case report on the use of processed Glycyrrhiza uralensis extract and Korean medical treatment for a patient with Amyotrophic Lateral Sclerosis(ALS)※

Abstract

Objectives:

The serum creatine kinase(CK) level of Amyotrophic Lateral Sclerosis(ALS) patients suggests that it may be an independent prognostic factor for the survival of ALS. We report the changes of serum CK level of ALS patients treated by administering processed Glycyrrhiza uralensis extracts and Korean medical treatments.

Methods:

We provided an ALS patient with processed Glycyrrhiza uralensis extracts and Korean medical treatments including acupuncture, pharmacopuncture and herbal medicine. The serum CK level was checked every month. The changes of ALSFRS-R and MRC grade were checked every month for additional result.

Results:

The serum CK level as the prognostic factor for the survival of ALS gradually decreased for three months. However, ALSFRS-R decreased by two points at the second trial. MRC rate had no change for three months.

Conclusion:

Combined administration of processed Glycyrrhiza uralensis extracts and Korean medical treatment could be meaningful possibilities in the treatment of ALS. We should conduct further studies to solve the limitations of this case study.

Notes

This study was supported by the Traditional Korean Medicine R&D Program funded by the Ministry of Health & Welfare through the Korea Health Industry Development Institute(KHIDI) (HI11C2142).

Table 1
Processed Glycyrrhiza uralensis extract administration
Date 2016.1.4–2016.2.11 2016.2.12–2016.2.18 2016.2.19–2016.4.22

Dose 4.32 g/d ceased 4.32 g/d
Table 2
Herbal Medicine Treatment
Date Herbal medicine
2016.1.4~2.10 Curcuma longa 6 g, Salvia miltiorrhiza 6 g, Gastrodia elata 8 g, Chaenomeles sinensis 6 g, Polygala tenuifolia 6 g, Paeonia japonica 6 g, Atractylodes japonicam 6 g and processed Aconitum carmichaeli (manufactured by Hanpoong Co., Ltd. Aconibal Tab.)
2016.2.17.~3.1 Panax ginseng 10 g, Astragalus membranaceus 10 g, Salvia miltiorrhiza 15 g, Chaenomeles sinensis 4 g, Crataegus pinnatifida 4 g, Amomum cadamomum Linné 4 g, Amomum villosum 4 g, Atractylodes japonica 8 g
2016.3.4~4.22 Curcuma longa 6 g, Salvia miltiorrhiza 6 g, Gastrodia elata 8 g, Chaenomeles sinensis 6 g, Polygala tenuifolia 6 g, Paeonia japonica 6 g, Atractylodes japonicam 6 g and processed Aconitum carmichaeli (manufactured by Hanpoong Co., Ltd. Aconibal Tab.)
Table 3
Changes of serum creatine kinase level
Date Creatine Kinase level (reference value: 24–195)
2016.1.4 250.0H
2016.2.13 242.0H
2016.3.14 212.0H
Table 4
Changes of ALSFRS-R score
2016.1.5 2016.2.15 2016.3.15
Speech 3 3 3
Salivation 4 4 4
Swallowing 4 4 4
Handwriting 3 2 2
Cutting food and Handling utensils (patients without gastrostomy-feeding tube) 3 2 2
Dressing and Hygiene 3 3 3
Turning in Bed and Adjusting Bed Clothes 2 2 2
Walking 2 2 2
Climbing Stairs 1 1 1
Dyspnea 4 4 4
Orthopnea 4 4 4
Respiratory insufficiency 4 4 4
K-ALSFRS-R 37 35 35
Score
Table 5
Changes of MRC grade
2016.1.4 2016.2.15 2016.3.15

right left right left right left
shoulder 4+ 4+ 4+ 4+ 4+ 4+
elbow 4+ 4+ 4+ 4+ 4+ 4+
wrist 4 4 4 4 4 4
finger 4+ 4+ 4+ 4+ 4+ 4+
hip 4+ 4+ 4+ 4+ 4+ 4+
knee 4+ 4+ 4+ 4+ 4+ 4+
ankle 4+ 4+ 4+ 4+ 4+ 4+
1st toe 4+ 4+ 4+ 4+ 4+ 4+
Table 6
Changes of liver function test
AST(12–33) ALT(5–35) ALP(96–254)
2016.1.4 22.0 25.0 153.0
2016.2.13 27.0 46.0 136.0
2016.3.14 20.0 32.0 119.0

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