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J Acupunct Res > Volume 32(4); 2015 > Article
Jung, Sung, Lim, Lee, Jo, Roh, and Lee: A Study on the Correlation between Pain Intensity and HbA1c for Diabetic Peripheral Neuropathy Patients※
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Abstract

Objectives:

The purpose of this study is to evaluate the correlation between HbA1c and pain intensity in diabetic peripheral neuropathy patients, and to compare the difference between two groups divided by the risk of complications.

Methods:

The participants were 46 men and women suffering from neuropathic pain diagnosed with diabetes mellitus who visited the Hospital of Traditional Korean Medicine, Semyung University from June, 2014 to August 2015. Age, duration of diabetes mellitus, numeric rating scale(NRS), and Michigan neuropathy screening instrument(MNSI) were used as evaluation tools.

Results:

  1. In all 46 cases, there were no significant correlations between HbA1c and age, duration of diabetes mellitus, NRS, MNSIQ, or MNSIE.

  2. Among 23 cases with a high risk of complications (more than 7.0 % of HbA1c, group A), there were no significant correlations between HbA1c and age, duration of diabetes mellitus, NRS, MNSIQ, or MNSIE.

  3. Among 23 cases with a low risk of complications(less than 7.0 % of HbA1c, group B), there were no significant correlations between HbA1c and age, duration of diabetes mellitus, NRS, MNSIQ, or MNSIE.

  4. Means of duration of diabetes mellitus, NRS, MNSIQ, and MNSIE were higher in group A than group B, but there were no significant correlations in statistics.

Conclusions:

This study could not find statistically significant correlations between pain intensity and HbA1c in diabetic peripheral neuropathy patients, so more studies are required in the future.

Fig. 1
10g Monofilament Test
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Table 1
General Characteristics
N* Age Duration of Diabetes Mellitus(year)
Male 26 63.35±9.88 11.37±9.43
Female 20 62.55±7.12 11.85±8.89
Total 46 63.00±8.71 11.58±9.10

* Number of patients

Table 2
HbA1c Distribution in Patients with Diabetic Peripheral Neuropathy
N* HbA1c(%)
High risk of complications (more than 7.0 % of HbA1c, group A) 23 9.18±1.78
Low risk of complications (less than 7.0 % of HbA1c, group B) 23 6.30±0.32
Total 46 7.74±1.93

* Number of patients

Table 3
Correlations of HbA1c with Age
Age Total Group A Group B
HbA1c Pearson correlation −0.180 −0.009 −0.124
p-value 0.231 0.968 0.573
N* 46 23 23

* Number of patients

Table 4
Correlations of HbA1c with Duration of Diabetes Mellitus
Duration of Diabetes Mellitus Total Group A Group B
HbA1c Pearson correlation 0.234 0.049 0.358
p-value 0.118 0.823 0.094
N* 46 23 23

* Number of patients

Table 5
Correlations of HbA1c with NRS
NRS Total Group A Group B
HbA1c Pearson correlation 0.036 0.037 −0.029
p-value 0.814 0.868 0.896
N* 46 23 23

* Number of patients

Table 6
Correlations of HbA1c with MNSIQ
MNSIQ Total Group A Group B
HbA1c Pearson correlation 0.167 0.092 −0.098
p-value 0.266 0.678 0.657
N* 46 23 23

* Number of patients

Table 7
Correlations of HbA1c with MNSIE
MNSIE Total Group A Group B
HbA1c Pearson correlation 0.018 −0.285 −0.230
p-value 0.908 0.188 0.291
N* 46 23 23

* Number of patients

Table 8
Comparison on Age, Duration of Diabetes Mellitus, NRS, MNSIQ, MNSIE between Group A and Group B
Group A Group B p-value
Age 61.09±10.38 64.91 ±6.30 0.140
Duration of Diabetes Mellitus(year) 13.79±10.24 9.37±7.38 0.101
NRS 6.04±1.49 5.96±1.58 0.849
MNSIQ 5.00±1.45 4.39±1.83 0.217
MNSIE 2.91 ±0.85 2.57±0.59 0.114
VI.
VI.

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