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J Acupunct Res > Volume 32(3); 2015 > Article
Seo, Shin, Kim, Seo, Seo, Park, Yoon, Jang, Song, and Kim: Clinical Research of the Effects of Sumsu (Bufonis venenum) Pharmacopuncture on Insomnia and Depression in Patients with Sleep Disorder
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Abstract

Objectives:

The purpose of this study is to investigate the effects of Sumsu (Bufonis venenum) pharmacopuncture on insomnia and depression.

Methods:

We investigated 32 patients with a sleep disorder who had been recruited at a Korean medical hospital from March 1st, 2014 to April 16th, 2015. We divided subjects into two groups : The control group(N=15) was treated with Normal Saline and the experimental group(N=17) was treated with Sumsu(Bufonis venenum) pharmacopuncture. The subjects were injected with 0.05 ml~0.1 ml, for a total of 0.6 ml on each acupuncture point. These were Pungbu(GV16), Pungi(GB20), Gyeonjeong(GB21), and Anmyun(EX-HN20). Both groups were evaluated with the beck depression inventory(BDI) and given an insomnia score before treatment, after one week, two weeks and four weeks from the initial visit.

Results:

The Insomnia score and BDI decreased significantly in the experimental group. In comparing the control group with the experimental group, there was a more significant improvement of the insomnia score in the experimental group during all periods of this study. However, the difference of change in BDI between the control group and experimental group was only significant in the first week.

Conclusions:

Sumsu(Bufonis venenum) pharmacopuncture can be used as an effective treatment for patients with insomnia and depression.

Table 1
General Characteristics
Control group(n=17) Experimental group(n=15) p-value
Age 59.40±7.917 59.24±7.093 0.951*
Experience of sleeping pills + 4 + 3 0.678**
11 14
Insomnia 42.53±8.71 45.53±6.90 0.295*
BDI 11.40±2.82 14.24±2.20 0.132***

* independent samples t-test, p>0.05.

** Chi-square test, p>0.05.

*** Mann-Whitney U test, p>0.05.

Table 2
The Average of Insomnia Score in Each Group
Control group Experimental group
P0 42.53±8.71 45.53±6.90
P1 41.53±8.41 37.35±8.38
P2 39.87±7.81 38.18±6.64
P3 39.27±9.59 35.94±8.04

P0 : score at first visit.

P1 : score after one week from first visit.

P2 : score after two weeks from first visit.

P3 : score after four weeks from first visit.

Score after two weeks from the last treatment.

Table 3
The Periodical Difference of Insomnia Score in Each Group
Control group Experimental group

Z or t p-value Z or t p-value
P01 0.768 0.455 −3.410 0.001**
P02 1.676 0.116 4.824 0.000***
P03 2.977 0.010* 5.475 0.000***

P01 : period from the first visit to one week later.

P02 : period from the first visit to two weeks later.

P03 : period from the first visit to four weeks later.

* p-value < 0.05 by paired t-test.

** p-value < 0.01 by Wilcoxon signed rank test

*** p-value < 0.001 by paired t-test

Table 4
The Comparison of the Variation of Insomnia Score between Control Group and Experimental Group
Control Group Experimetal Group Z or t p-value
P01 1.00±5.04 8.18±7.42 −2.859 0.004*
P02 2.67±6.16 7.35±6.28 −2.127 0.042**
P03 3.27±4.25 9.59±7.22 −3.059 0.005***

P01 : period from the first visit to one week later.

P02 : period from the first visit to two weeks later.

P03 : period from the first visit to four weeks later.

* p-value < 0.01 by Mann-Whiteney test

** p-value < 0.05 by independeant samples t-test

*** p-value < 0.01 by independeant samples t-test

Table 5
The Average of BDI in Each Group
Control group Experimental group
P0 11.40±10.95 14.24±9.05
P1 10.13±11.00 10.59±9.19
P2 9.07±10.59 12.00±12.19
P3 9.13±11.62 10.88±10.90

P0 : score at first visit.

P1 : score after one week from first visit.

P2 : score after two weeks from first visit.

P3 : score after four weeks from first visit.

Score after two weeks from the last treatment.

Table 6
The Periodical Difference of BDI in Each Group
Control group Experimental group

Z or t p-value Z or t p-value
P01 1.456 0.167 5.404 0.000*
P02 −1.617 0.106 1.582 0.133
P03 1.734 0.105 3.127 0.006**

P01 : Period from the first visit to one week later.

P02 : Period from the first visit to two weeks later.

P03 : Period from the first visit to four weeks later.

* p-value < 0.001 by paired t-test

** p-value < 0.01 by paired t-test

Table 7
The Comparison of the Variation of BDI between Control Group and Experimental Group
Control Group Experimetal Group Z or t p-value
P01 1.27±3.37 3.65±2.78 −2.162 0.040*
P02 2.33±5.74 2.24±5.83 −0.799 0.433
P03 2.27±5.06 3.35±4.36 −0.646 0.523

P01 : period from the first visit to one week later.

P02 : period from the first visit to two weeks later.

P03 : period from the first visit to four weeks later.

* p-value < 0.05 by independeant samples t-test.

VI.
VI.

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