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J Acupunct Res > Volume 31(2); 2014 > Article
Kim, Kim, Jeong, Kim, Kim, Park, Yang, Kim, Jo, Kim, and Cho: Comparison Study for Effects of Pharmacopunctures of GB40 on Weight Bearing Ratio in Grade III Ankle Sprain Model※

Abstract

Objectives:

This study was aimed to determine which pharmacopuncture was effective in relieving pain in standard pain model, acute grade 3 ankle sprain rat model.

Methods:

Percentage changes of weight bearing ratio(WBR), as pain indicator, were measured after anti-inflammation, neutro Eohyul, Hwangryunhaedock-decoction pharmacopuncture were injected to Guheo(GB40).

Results:

In three kinds of pharmacopuncture, neutro Eohyul and Hwangryunhaedock-decoction pharmacopuncture represented more effect in percentage changes of WBR than surgical(non treatment), needling group.

Conclusions:

Comparing of pharmacopuncture in grade 3 ankle sprain rat model, these results provide basis to select pharmacopuncture in sprain disease. Furthermore, mechanism of pharmacopuncture’s analgesia, anti-inflammation should be progressed.

Notes

This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(NRF-2012R1A1A4A01004637)

Fig. 1.
Comparison of normal group and ankle surgical sprain group
Weight bearing ratio stands for foot steping force to body weight.
Foot steping force were measured as highest foot stepping force of the hind limb of ankle sprained rat.
The data were expressed mean ± SE of weingt bearing ratio.
acupunct-31-2-11-2f1.tif
Fig. 2.
Effect of anti-inflammation pharmaco-puncture applied to GB40 on changes of WBR ratio in a ankle sprain rat
Control group were consisted of sprain group(non treated group) and needling group.
Needling group were needled to GB40 in 5 seconds. Anti-inflammation group were injected anti-inflammation pharmacopuncture 50 μl to GB40 in 5 seconds.
The data were expressed mean ± SE of percent changes in weight bearing ratio.
* : statistically significant compared with sprain group(*:p<0.05)
acupunct-31-2-11-2f2.tif
Fig. 3.
Effect of neutro Eohyul pharmaco-puncture applied to GB40 on changes of WBR ratio in a ankle sprain rat
Neutro Eohyul group were injected neutro Eohyul pharmaco-puncture 50 μl to GB40 in 5 seconds.
The data were expressed mean ± SE of percent changes in weight bearing ratio.
*, # : statistically significant compared with sprain group, needling group respectively(*, # : p<0.05)
acupunct-31-2-11-2f3.tif
Fig. 4.
Effect of Hwangryunhaedock-decoction pharmacopuncture applied to GB40 on changes of WBR ratio in a ankle sprain rat
Hwangryunhaedock-decoction group were injected Hwangryunhaedock-decoction pharmacopuncture 50 μl to GB40 in 5 seconds.
The data were expressed mean ± SE of percent changes in weight bearing ratio.
*, # : statistically significant compared with sprain group, needling group respectively(*, # : p<0.05)
acupunct-31-2-11-2f4.tif
Fig. 5.
Comparison of neutro Ehoyul and Hwang-ryunhaedock-decoction pharmacopuncture applied to GB40 on changes of WBR ratio in a ankle sprain rat
The data were expressed mean ± SE of percent changes in weight bearing ratio.
acupunct-31-2-11-2f5.tif

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