Comparison Study for Effects of Pharmacopunctures of GB on Weight Bearing Ratio in Grade III Ankle Sprain Model

Sul Gi Kim; Seong Joung Kim; Ho Hyun Jeong; June Hyun Kim; Do Ho Kim; Sueng Hyuk Park; Seung Bum Yang; Jae Hyo Kim; Eun Heui Jo; Sung Chul Kim; Nam Geun Cho

doi:10.13045/acupunct.2014020

J Acupunct Res > Volume 31(2); 2014 > Article

Kim, Kim, Jeong, Kim, Kim, Park, Yang, Kim, Jo, Kim, and Cho: Comparison Study for Effects of Pharmacopunctures of GB40 on Weight Bearing Ratio in Grade III Ankle Sprain Model※

Original Article

The Acupuncture 2014; 31(2): 11-19.

Published online: June 20, 2014

DOI: https://doi.org/10.13045/acupunct.2014020

Comparison Study for Effects of Pharmacopunctures of GB₄₀ on Weight Bearing Ratio in Grade III Ankle Sprain Model^※

Sul Gi Kim¹, Seong Joung Kim¹, Ho Hyun Jeong¹, June Hyun Kim¹, Do Ho Kim¹, Sueng Hyuk Park², Seung Bum Yang³, Jae Hyo Kim³, Eun Heui Jo¹, Sung Chul Kim¹, Nam Geun Cho^1,^*

¹Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Wonkwang University

²Department of Physiology, College of Korean Medicine, Wonkwang University

³Department of Meridian & Acupoint, College of Korean Medicine, Wonkwang University

^* Corresponding author : Department of Acupuncture & Moxibustion Medicine, College of Korean Medicine, Wonkwang University, 895, Muwang-ro, Iksan-si, Jeollabuk-do, 570-754, Republic of Korea, Tel : +82-63-859-2812 E-mail : choandle@hanmail.net

Received April 24, 2014 Revised April 24, 2014 Accepted May 26, 2014

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract

Objectives:

This study was aimed to determine which pharmacopuncture was effective in relieving pain in standard pain model, acute grade 3 ankle sprain rat model.

Methods:

Percentage changes of weight bearing ratio(WBR), as pain indicator, were measured after anti-inflammation, neutro Eohyul, Hwangryunhaedock-decoction pharmacopuncture were injected to Guheo(GB₄₀).

Results:

In three kinds of pharmacopuncture, neutro Eohyul and Hwangryunhaedock-decoction pharmacopuncture represented more effect in percentage changes of WBR than surgical(non treatment), needling group.

Conclusions:

Comparing of pharmacopuncture in grade 3 ankle sprain rat model, these results provide basis to select pharmacopuncture in sprain disease. Furthermore, mechanism of pharmacopuncture’s analgesia, anti-inflammation should be progressed.

Key Words: Ankle sprain; Pharmacopuncture; GB₄₀; Anti-inflammation pharmacopuncture; Neutro Eohyul pharmacopuncture; Hwangryunhaedock-decoction pharmacopuncture.

Notes

This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education(NRF-2012R1A1A4A01004637)

Fig. 1.

Comparison of normal group and ankle surgical sprain group

Weight bearing ratio stands for foot steping force to body weight.

Foot steping force were measured as highest foot stepping force of the hind limb of ankle sprained rat.

The data were expressed mean ± SE of weingt bearing ratio.

Fig. 2.

Effect of anti-inflammation pharmaco-puncture applied to GB₄₀ on changes of WBR ratio in a ankle sprain rat

Control group were consisted of sprain group(non treated group) and needling group.

Needling group were needled to GB₄₀ in 5 seconds. Anti-inflammation group were injected anti-inflammation pharmacopuncture 50 μl to GB₄₀ in 5 seconds.

The data were expressed mean ± SE of percent changes in weight bearing ratio.

^* : statistically significant compared with sprain group(^*:p<0.05)

Fig. 3.

Effect of neutro Eohyul pharmaco-puncture applied to GB₄₀ on changes of WBR ratio in a ankle sprain rat

Neutro Eohyul group were injected neutro Eohyul pharmaco-puncture 50 μl to GB₄₀ in 5 seconds.

The data were expressed mean ± SE of percent changes in weight bearing ratio.

^*, ^# : statistically significant compared with sprain group, needling group respectively(^*, ^# : p<0.05)

Fig. 4.

Effect of Hwangryunhaedock-decoction pharmacopuncture applied to GB₄₀ on changes of WBR ratio in a ankle sprain rat

Hwangryunhaedock-decoction group were injected Hwangryunhaedock-decoction pharmacopuncture 50 μl to GB₄₀ in 5 seconds.

The data were expressed mean ± SE of percent changes in weight bearing ratio.

^*, ^# : statistically significant compared with sprain group, needling group respectively(^*, ^# : p<0.05)

Fig. 5.

Comparison of neutro Ehoyul and Hwang-ryunhaedock-decoction pharmacopuncture applied to GB₄₀ on changes of WBR ratio in a ankle sprain rat

The data were expressed mean ± SE of percent changes in weight bearing ratio.

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