Effect of Herbal Medicines Pharmacopuncture on Hair Growth, a Review of Animal Study Reports Published in Koreae

Article information

Acupunct. 2014;31(1):139-148
Publication date (electronic) : 2014 March 20
doi : https://doi.org/10.13045/acupunct.2014014
1Gtaduate School of East-West Medical Science, Kyung Hee University
2Acupucture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University
*Corresponding author : Acupucture and Meridian Science Research Center, College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdeamun-gu, Seoul 130-701, Republic of Korea, Tel : +82-2-961-0975 E-mail : acuyin@khu.ac.kr
Received 2014 January 22; Revised 2014 February 28; Accepted 2014 March 05.

Abstract

Objectives :

The aim of this study was to review the effect of herbal medicine on hair growth in animal models reported in Korean domestic journals.

Methods :

Korean core databases were searched with terms alopecia and hair, and animal study reports on hair growth with herbal medicine were reviewed. Animal model, intervention, and hair growth measure data were extracted.

Results :

A total of 28 reports were reviewed. C57BL/6 mice with depilation was the most frequent animal models used. Polygoni multiflori radix, Cnidii rhizoma and Biotae Folium were frequently used herbal medicine. Positive effects were reported.

Conclusions :

Herbal medicines may be promising resource for pharmacopuncture materials for positive effects on hair growth.

Fig. 1.

Flow chart for searching strategy

Fig. 2.

The number of published studies is analyzed by the observation methods of measuring indicators

M : macroscopy.

H : histological examination.

I : immunological examination.

Resources Search Site

Summary of Animal Model in Studies

Summary of Intervention in Study

Frequency of Herbal Materials that Constitute the Intervention for Hair Growth

Summary of the Measuring Indicators and Results

Notes

This research was supported by Basic Science Research Program through the National Research Foundation of Korea(NRF) funded by the Ministry of Education, Science and Technology (No. 2005-0049404)

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Article information Continued

Fig. 1.

Flow chart for searching strategy

Fig. 2.

The number of published studies is analyzed by the observation methods of measuring indicators

M : macroscopy.

H : histological examination.

I : immunological examination.

Table 2.

Summary of Animal Model in Studies

No. First author(year) Subject Age(week) Sex Depilation method
1 Ha et al21)(2013) C57BL/6 5 Male De
2 Kim et al22)(2012) C57BL/6 4 Male Cl + De
3 Ryu et al23)(2011) C57BL/6 6 Female Cl
4 Do et al24)(2011) C57BL/6 6 Male Cl + De
5 Choi et al25)(2011) C57BL/6 5 Male Cl + De
6 Lee et al26)(2010) C57BL/6 6 Female Cl
7 Hue et al27)(2010) C57BL/6 6 Male Cl
8 Hong et al28)(2010) C57BL/6 5 female Cl + De
9 Kwon et al29)(2009) C57BL/6 7, 21↑ Female, male Cl
10 Lee et al30)(2009) C57BL/6 5 Male Cl
11 Cho et al31)(2009) C57BL/6 5 Male De
12 Chung et al32)(2009) C57BL/6 8 Male Cl
13 Jeong et al33)(2009) C57BL/6 7, 21↑ Male Cl
14 Han et al34)(2009) C57BL/6 5 Female Cl + De
15 Jo et al35)(2008) C57BL/6 7 Male Cl + De
16 Park et al36)(2008) C57BL/6 5 female Cl
17 Lee et al37)(2008) C57BL/6 7, 21↑ Male Cl
18 Jung et al38)(2007) C57BL/6 6 Male Cl + De
19 Hyung et al39)(2007) C57BL/6 5 Female Cl
20 Lee et al40)(2007) C57BL/6 5 Female Cl + De
21 Hyung et al41)(2007) C57BL/6 5 Male Cl
22 Tak et al42)(2007) C57BL/6 6 - Cl + De
23 Na et al43)(2006) C57BL/6 6 Male Cl + De
24 Hue et al44)(2005) C57BL/6 5 Female, male Cl
25 Kwon et al45)(2004) C57BL/6 52↑ Female -
26 Nam et al46)(2004) C57BL/6 5 Male Cl
27 Lee et al47)(2004) SD(Spargue-Dawley) 12 Male -
28 Kim et al48)(2004) C57BL/6 5 Female Cl
29 Choi et al49)(2003) C3H/HeSlc 8 - Cl

De : depilatory. Cl : clipper.

Table 3.

Summary of Intervention in Study

No. Simple, complex Herb material Method Period (day)
121) Complex Undaria pinnatifida·Laminaria·Hizikia fusiforme·Porphyra tenera ·Glycine max·Sesamum indicum L·Arctium lappa·Ginseng Radix Alba·Pine·Polygoni Multiflori Radix·Angelicae Gigantis Radix·Poria cocas Wolf·Cnidii Rhizoma Application 14
222) Complex Rosa multiflora root ·Pueraria radix root·Undaria pinnatifida·Zea mays root·Glycine max· Artemisia princeps Pampan Application 14
323) Simple Soarassis crispa Wulf Application 28
424) Complex Ginseng Radix Alba ·Polygoni Multiflori Radix·Poria cocas Wolf·Rehmanniae Radix et Rhizoma Preparata·Honey Application 21
525) Complex Tonic : Mori Folium·Biotae Folium·Sesamum indicum L·Laminaria·Undaria pinnatifida Food : Mori Folium·Biotae Folium·Pini Folium·Sesamum indicum L·Lycii Fructus ·Glycine max· Undaria pinnatifida·Ginseng Radix Rubra Application O/A 21
626) Simple Chaff vinegar liquor Application 14
727) Simple Sodium Metasilicate(Na2SiO3) Application 21
828) Complex Astragali Radix·Atractylodis Rhizoma Alba ·Crataegus pinnatifida·Cyperi Rhizoma· Pinelliae Tuber·Citri Unshii Pericarpium·Poria cocas Wolf·Triticum aestivum·Hordei Fructus Germinatus· Glycyrrhizae Radix et Rhizoma·Magnoliae Cortex·Amomi Fructus·Body of Korean angelica· Paeoniae Radix·Rehmanniae Radix·Ginseng Radix Alba·Pachyma hoelen·Liriopis Tuber·Polygalae Radix·Cnidii Rhizoma·Aucklandiae Radix·Zingiberis Rhizoma Crudus·Zizyphus jujuba var O/A 14
929) Simple Arisaematis Rhizoma Application 15
1030) Complex Mori Cortex Radicis·Polygoni Multiflori Radix Application 21
1131) Simple Wood vinegar Application 14
1232) Complex Mylabris cichorii·Mylabris phalerata·Arisaema amurense ·Pinelliae Tuber Application 16
1333) Simple Pinelliae Tuber Application 16
1434) Complex Polygoni Multiflori Radix·Angelicae Gigantis Radix·Rehmanniae Radix Crudus·Ligustrum japonicum·Biotae Folium·Glycine max·Sesami Semen·Ecliptae Herba·Viticis Fructus·Paeonia papaveracea Application 12
1535) Simple Mylabris cichorii Application 21
1636) Simple Chamaecyparidis Folium Application 28
1737) Complex Mylabris cichorii·Drynaria fortunei Application 15
1838) Simple Drynaria fortunei Application 21
1939) Complex Morus ·black sesame·Thujae Orientalis Folium·Galla Rhois·Glycyrrhizae Radix et Rhizoma· Ginseng Radix Alba·Cnidii Rhizoma Application 21
2040) Complex Artemisiae Asiaticae Herba ·Angelicae Gigantis Radix·Thujae Orientalis Folium·Sophora Root· Angelicae Dahuricae Radix·Actaea asiatica Hara·Atractylodis Rhizoma ·Granati Pericarpium Application 14
2141) Complex Rosemary·Peppermint Application 28
2242) Simple Thujae Orientalis Folium Application 21
2343) Simple Mori Cortex Radicis Application 16
2444) Complex Swertiae Herba·Ginseng Radix Alba Application 21
2545) Complex Swertiae Herba·Saposhnikoviae Radix·Bupleuri Radix·Viticis Fructus·Rehmanniae Radix· Paeonia japonica·Cnidii Rhizoma·Scutellariae Radix ·Lycii Fructus·Cuscutae Semen·Rubi Fructus·Schisandrae Fructus·Schizonepetae Spica·Angelicae Tenuissimae Radix ·Cnidi Fructus Application O/A 70
2646) Complex Gardeniae Fructus·Acori Calami Rhizoma ·Mori Cortex Radicis·Aloe Application 14
2747) Complex Polygoni Multiflori Radix·Angelicae Gigantis Radix·Lycii Fructus O/A 35
2848) Complex Rehmannia glutinosa var purpurea ·Angelicae Gigantis Radix·Cnidii Rhizoma·Paeonia japonica· Cinnamon Bark·Carthami Flos·Polygoni Multiflori Radix Application 30
2949) Complex Glycyrrhizae Radix et Rhizoma ·Persicae Semen·Salviae Miltiorrhizae Radix·Angelicae Gigantis Radix·Dichroa febrifuga·Ginseng Radix Alba·Cnidii Rhizoma·Carthami Flos Application 21

Table 4.

Frequency of Herbal Materials that Constitute the Intervention for Hair Growth

Frequency Herb Material
6 Polygoni multiflori radix·Cnidii rhizoma·Biotae Folium
5 Ginseng Radix Alba·Angelicae Gigantis Radix
4 Glycine max
3 Poria cocas Wolf·Pinelliae Tuber·Mylabris phalerata·Body of Korean angelica·Mori Cortex Radicis·Lycii Fructus·Rehmanniae Radix·Paeonia japonica·Glycyrrhizae Radix et Rhizoma· Undaria pinnatifida
2 Arctium lappa·Mori Folium·Sesamum indicum L·Viticis Fructus·Carthami Flos

Table 5.

Summary of the Measuring Indicators and Results

No. Measuring Indicators
121) Photographing, HRS, hair density, hair thickness, hair follicle length and thickness, histological observation (longitudinal section), IGF-1, TGF-β1
222) Photographing, HRS
323) Photographing, HRS, histological observation(transverse section)
424) Photographing, hair density, Hair thickness, IGF-1, VEGF
525) Photographing, hair density, Hair thickness, IGF-1
626) Photographing, histological observation(transverse section), IGF-1, VEGF, KGF, HGF
727) Photographing, HRS, histological observation(longitudinal section), ALP, γ-GT, EGF, VEGF, TGF-β1
828) Photographing, HRS, histological observation(longitudinal, transverse section), TGF-β1, EGF, IFN-γ, IL-4, IL-10
929) Photographing, Histological observation(longitudinal section), TGF-β, IGF, prolactin, placenta lactogen, VEGF, c-kit, PKC-α, TGF, FGF
1030) Photographing, HRS, ALP, γ-GT, IGF-1, TGF-β
1131) Photographing, HRS
1232) Photographing, histological observation(longitudinal section), VEGF, FGF, c-kit, PKC-α, bFGF, IGF-1, PL1
1333) Photographing, Histological observation(longitudinal section), TGF-β, IGF, prolactin, placenta lactogen
1434) Photographing, HRS, histological observation(longitudinal section), EGF, TGF-β1, IL-6, TNF-α, IL-1β
1535) Photographing
1636) Photographing, HRS, ALP, γ-GT
1737) Photographing, histological observation(longitudinal section), VEGF, c-kit, PKC-α, TGF-β, prolactin, placenta lactogen
1838) Photographing, histological observation(longitudinal section), Skin thickness, Mast cell count, VEGF, PKC-α, SCF
1939) Photographing, HRS, histological observation(longitudinal section)
2040) Photographing, HRS, histological observation(longitudinal section), TBF-β1, EGF
2141) Photographing, HRS, histological observation(longitudinal, transverse section)
2242) Photographing, histological observation(longitudinal section), VEGF, PKC-α, SCF
2343) Photographing, histological observation(longitudinal section)
2444) Photographing, histological observation(longitudinal section), ALP, γ-GT
2545) Photographing, histological observation(longitudinal section), substance P, CRF, CRF-R, CRF-BP
2646) Photographing, HRC, histological observation(longitudinal section), IGF-1, TGF-β
2747) Histological observation(transverse section), skin total(T+DHT), DHT
2848) Photographing, HRS
2949) Photographing

HRS : hair regrowth score. IGF : insulin-like growth factor. TGF : transformation growth factor.

VEGF : vascular endothelial growth factor. KGF : keratinocyte growth factor. HGF : hepatocyte growth factor.

ALP : alkaline phosphatase. GT : glutamyl transpeptidase. EGF : epithelial growth factor. IL : interleukin.

PKC : protein kinase C activator. FGF : fibroblast growth factor. CRF : dorticotropin releasing factor.

DHT : dihydrotestosterone.