The Effect of Venesection with Cupping Therapy at Jeonjung(CV17) on the Heart Rate Variability in Healthy Adults

Article information

J Korean Acupunct Moxib Soc. 2013;30(4):15-24
Publication date (electronic) : 2013 September 20
doi : https://doi.org/10.13045/acupunct.2013018
1Department of Acupuncture & Moxibustion Medicine, Wonkwang University Oriental Medicine Hospital
2Department of Oriental Medical Ophthalmology & Otolaryngology & Dermatology, Wonkwang University Oriental Medicine Hospital
3Research Center of Traditional Korean Medicine, Wonkwang University
4Department of Radiology, Wonkwang University Oriental Medicine Hospital

This research was supported by a grant from Wonkwang University in 2013

*Corresponding author : Department of Acupuncture & Moxibustion Medicine, Wonkwang University Oriental Medicine Hospital, 99, Garyeonsan-ro, Deokjin-gu, Jeonju-si, Jeollabuk-do, 561-851, Republic of Korea, Tel : +82-63-270-1022 E-mail : freezo@wonkwang.ac.kr
Received 2013 July 17; Revised 2013 August 15; Accepted 2013 August 16.

Abstract

Objectives :

This study was accomplished to investigate the effects of venesection with cupping therapy at Jeonjung(CV17) on the heart rate variability(HRV) in healthy adults. And based on that, we tried to find out how venesection with cupping therapy at Jeonjung(CV17) affects the activity and the balance of the autonomic nervous system.

Methods :

We investigated on 60 healthy volunteers consisted of 30 subjects in venesection with cupping therapy group and 30 subjects in control group. The study was established by randomized trial. venesection with cupping therapy was applied at Jeonjung(CV17) for 10 minutes in venesection with cupping therapy group. No treatment was executed in control group. We measured HRV 3 times : First, baseline measurement and two more times after treatment in venesection with cupping therapy group(after rest in control group). The SPSS 12.0 for Windows was used to analyze the data by paired t-test(in both group), independent-test(between the groups) and Chi-square test(between the sexs).

Results :

  1. In venesection with cupping therapy group, SDNN, Ln(TP), Ln(LF), Normalized LF, and LF/HF ratio increased significantly. Normalized HF decreased significantly. Mean HRT, RMSSD, PSI, Ln(HF), and Ln(VLF) were not affected.

  2. In control group, Ln(HF) decreased significantly. Mean HRT, SDNN, RMSSD, PSI, Ln(TP), Ln(LF), Ln(VLF), Normalized LF, Normalized HF, and LF/HF ratio were not affected.

Conclusions :

This study suggests that venesection with cupping therapy at Jeonjung(CV17) increases the activity of the autonomic nervous system and has effects on the balance of the autonomic nervous system.

Fig. 1.

Protocol of experiment

General Characteristics

The Comparison of Mean HRT between Venesection with Cupping Therapy Group and Control Group

The Comparison of SDNN between Venesection with Cupping Therapy Group and Control Group

The Comparison of RMSSD between Venesection with Cupping Therapy Group and Control Group

The Comparison of PSI between Venesection with Cupping Therapy Group and Control Group

The Comparison of Ln(TP) between Venesection with Cupping Therapy Group and Control Group

The Comparison of Ln(LF) between Venesection with Cupping Therapy Group and Control Group

The Comparison of Ln(HF) between Venesection with Cupping Therapy Group and Control Group

The Comparison of Ln(VLF) between Venesection with Cupping Therapy Group and Control Group

The Comparison of Norm LF between Venesection with Cupping Therapy Group and Control Group

The Comparison of Norm HF between Venesection with Cupping Therapy Group and Control Group

The Comparison of LF/HF Ratio between Venesection with Cupping Therapy Group and Control Group

References

1. Yuji Murakawa. Steps to Internal Medicine. New pathophysiology Jung-dam Publishing; 2008. 10p. 20–1.
2. Kamath MV, Fallen EL. Power spectral analysis of heart rate variability: a noninvasive signature of cardiac autonomic function. Crit Rev Biomed Eng 1993;21(3):245–311.
3. Jin-soo Park, Min-seob Ahn, Jeong-ju Lee, et al. Study on the Effect of Acupuncture at Jeongjung (CV17) on the Heart Rate Variability in Healthy Adult. The Journal of Korean Acupuncture & Moxibustion Society 2011;28(2):13–25.
4. Park Eun Young, Jang Jeong A, Kim Hyun Jin, et al. Effects of LI4, Liv3 Acupuncture for Mental Stress on Short-term Analysis of Heart Rate Variability. J of Oriental Neuropsychiatry 2010;21(4):163–73.
5. Lee Ji Hye, Choi Young Joon, Shin Byung Chul, et al. Differential Effects of Tow Individual Acupuncture Points(BL62,KI6) on Heart Rate Variability in Healthy Volunteers: A Randomized, Single-Blind, Self-Controlled Trial. Korean Journal of Acupuncture 2010;27(4):85–96.
6. Seonguk Park, Woosang Jung, Sangkwan Moon, et al. Effects of Acupuncture on Autonomic Nervous System in Normal Subjects under Mental Stress. Journal of Korean Oriental Medical society 2008;29(2):107–15.
7. Korean Acupuncture & Moxibustion Society. The Acupuncture and Moxibustion Paju: Jipmoondang; 1998. p. 1066. p. 1243.
8. Gukjeong Lee, Yakhyang Lee. Dong Ssi Chim Gu Bang Hyeol Yo Beop(Dong Ssi Acupuncture and Venesection Therapy) Dae Buk: Won Ji Seo Guk; 1994. p. 4–14.
9. Nam Tong-Hyun, Park Young-Bae. Study of Gender and Age-Related Differences in the Pulse Rate Variability. Journal of korean Institute of Oriental Medical Diagnostics 2001;5(2):332–50.
10. Korean Acupuncture & Moxibustion Society. The Acupuncture and Moxibustion Paju: Jipmoondang; 2012. p. 325–38.
11. Yang Dong In, Shim Young Woo, No Hyung Wook, Kim Deok Won. The effect of posture on HRV. The Korean Institue of Electrical Engineers 2009;(5):399–401.
12. Yen-tag Jeong, Yun-Kyoung Yim. 27 Case of Venesection with Negative Pressure Therapy(Buhang) Operated at CV17(Danjuong) on Sudden palpitation: case report. Department of Meridian & Acupoint, College of Oriental Medicine, Daejeon University 2007;16(2):199–210.
13. Korean Acupuncture & Moxibustion Society. The Acupuncture and Moxibustion Paju: Jipmoondang; 2012. p. 341.
14. Korean Acupuncture & Moxibustion Society. The Acupuncture and Moxibustion Paju: Jipmoondang; 2001. p. 1061–7.
15. Son Dae-Yong, Kim Min-Su, Kim Sang-Jin, et al. Comparison of Depletion and Cupping Therapy with Cupping Therapy on Acute Lum bosacral Strain Patients. Journal of oriental rehabilitation medicine 2003;13(4):53–61.
16. Jun-Kuy Lim. Dong Ui Ja Yeon Yo Beop Dae Jeon(The Book of Oriental Medicine natural Therapy) Seoul: Komoonsa; 1977. p. 109–111. p. 116.
17. Choi hyun-joo . Suppression of Cell-mediated Immune Responses by Ecchymosis induced by cupping Theray Professional Graduate school of Oriental Medicine Wonkwang university; 2004.
18. Niasari M, Kosari F, Ahmadi A. The effect of wet cupping on serum lipid concentrations of clinically healthy young men: a randomized controlled trial. J Altern Complement Med 2007;13(1):79–82.
19. Yungyeong Lim, Junpyo Kim, Taehan Kim. Detail of Meridians & Acupoints A Guidebook for College Students Daejeon: Yi Bang Medicalbook Center; 2006. p. 1042.
20. Yeonggi Ahn. Kyung Hyeol Hak Chong Seo Seoul: Seongbosa; 1986. p. 608–1. p. 672p. 702–3.
21. Kim Yong Woo, Lim Jong Kook. Study of the effects of moxibustion at the Jeun Jung(CV17) and Gyeong Su(BL17) on experimentally induced anemic rats. The J of Korean Acupuncture & Moxibustion Society 1992;9(1):193–202.
22. Shin KS, Minamitani H, Onishi S, Yamazaki H, Lee M. Autonomic difference Between athletes and nonathletes: spectral analysis approach. Med Sci sports Exerc 1997;29(11):1482–90.
23. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: Standards of measuremant, physiological interpretation and clinical use. Eur Heart J 1996;17(3):354–81.
24. Akselrod S, Gordon D, Shannon DC, Berger AC, Cohen RJ. Power spectrum analysis of heart rate fluctuation : a quantitative probe of beat-to-beat cardiovascular control. Science 1981;213(4504):220–2.
25. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. Heart rate variability: Standards of measuremant, physiological interpretation and clinical use. Eur Heart J 1996;17(3):354–81.
26. Min-su Kim, Min-ah Kwak, Woo-seo Jang, et al. Effect of Electroacupuncture Stimulation on Heart Rate Variability in Healthy Adults. The J of Korean Acupuncture & Moxibustion Society 2003;20(4):157–69.
27. Jeung-shin Kim, Wook Hwang, Ki-tae Bae, Sang-soo Nam, Yong suk Kim. Effect of Acupuncture for Mental Stress on Short-term Analysis of Heart Rate Variability(HRV). The J of Korean Acupuncture & Moxibustion Society 2004;21(5):227–40.
28. Korpelainen JT, Huikuri HV, Sotaniemi KA, Myllyla VV. Abnormal heart rate variability reflecting autonomic dysfunction in brainstem infarction. Acta Neurol Scand 1996;94(5):337–42.
29. Yu Gi Yong, Il Min Byung, Kim Ji Hoon, Lee Gwang Yun, Ko Eun Sang, Hong Mu Chang. The effect of sensory stimulation on different sites of the body on arterialpressures and heart rates. The J of Korean Acupuncture & Moxibustion Society 2002;19(1):147–58.

Article information Continued

Fig. 1.

Protocol of experiment

Table 1.

General Characteristics

BTx Control p-value
Age 27.67±5.08 28.83±5.07 NS(p>0.05)
Sex Male n=24 n=19 NS
Female n=6 n=11

Values are presented as mean±standard deviation.

Table 2.

The Comparison of Mean HRT between Venesection with Cupping Therapy Group and Control Group

M- HRV 1st HRV 2nd HRV 3rd HRV
Venesection with cupping therapy 73.27±11.59 72.50±11.37 72.73±11.15
Control 73.33±8.38 72.73±7.45 72.97±7.40

Mean HRT : mean heart rate.

Table 3.

The Comparison of SDNN between Venesection with Cupping Therapy Group and Control Group

SDNN 1st HRV 2nd HRV§ 3rd HRV
Venesection with cupping therapy*, 44.37±13.21 50.42±16.58 55.10±17.45
Control 46.01±13.27 45.80±14.35 45.54±13.51

SDNN : standard deviation of all normal R-R intervals.

*:

p-value < 0.05 between 1st and 2nd HRV.

†:

p-value < 0.05 between 1st and 3rd HRV.

§:

p-value < 0.05 between 1st and 2nd HRV.

¶:

p-value < 0.05, between 2nd and 3rd HRV.

Table 4.

The Comparison of RMSSD between Venesection with Cupping Therapy Group and Control Group

RMSSD 1st HRV 2nd HRV 3rd HRV
Venesection with cupping therapy 34.8812±15.4533 35.4444±17.0906 35.3290±15.6446
Control, 34.9898±11.2702 34.1849±13.01188 31.6977±11.9666

RMSSD : the square root of the mean of the sum of the squares of differences between adjacent normal R-R intervals.

†:

p-value < 0.05 between 1st and3 rd HRV.

‡:

p-value < 0.05, between 2nd and 3rd HRV.

Table 5.

The Comparison of PSI between Venesection with Cupping Therapy Group and Control Group

PSI 1st HRV 2nd HRV 3rd HRV
Venesection with cupping therapy*, 42.83±66.43 33.59±45.22 25.53±24.16
Control 31.34±19.63 30.78±17.36 31.14±15.65

PSI : physical stress index.

*:

p-value < 0.05 between 1st and 2nd HRV.

†:

p-value < 0.05 between 1st and 3rd HRV.

Table 6.

The Comparison of Ln(TP) between Venesection with Cupping Therapy Group and Control Group

Ln(TP) 1st HRV 2nd HRV 3rd HRV,
Venesection with cupping therapy, 7.22±0.71 7.43±0.81 7.73±0.82
Control 7.36±0.64 7.38±0.68 7.28±0.60

Ln(TP) : log-transformed total power.

†:

p-value < 0.05 between 1st and 3rd HRV.

‡:

p-value < 0.05 between 2nd and 3rd HRV.

‖:

p-value < 0.05 between 1st and 3rd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.

Table 7.

The Comparison of Ln(LF) between Venesection with Cupping Therapy Group and Control Group

Ln(LF) 1st HRV 2nd HRV§ 3rd HRV,
Venesection with cupping therapy, 6.07±0.98 6.30±0.99 6.80±0.84
Control 6.27±0.80 6.19±0.87 6.15±0.73

Ln(LF) : log-transformed low frequency power.

†:

p-value < 0.05 between 1st and 3rd HRV.

‡:

p-value < 0.05 between 2nd and 3rd HRV.

§:

p-value < 0.05 between 1st and 2nd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.

‖:

p-value < 0.05 between 1st and 3rd HRV.

Table 8.

The Comparison of Ln(HF) between Venesection with Cupping Therapy Group and Control Group

Ln(HF) 1st HRV 2nd HRV 3rd HRV,
Venesection with cupping therapy 5.56±1.08 5.46±1.23 5.57±1.09
Control, 5.77±0.78 5.67±0.88 5.45±0.81

Ln(HF) : log-transformed high frequency power.

†:

p-value < 0.05 between 1st and 3rd HRV.

‡:

p-value < 0.05 between 2nd and 3rd HRV.

‖:

p-value < 0.05 between 1st and 3rd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.

Table 9.

The Comparison of Ln(VLF) between Venesection with Cupping Therapy Group and Control Group

Ln(VLF) 1st HRV 2nd HRV 3rd HRV
Venesection with cupping therapy*, 6.16±0.83 6.60±0.81 6.74±1.02
Control 6.30±0.85 6.41±0.86 6.35±0.85

Ln(VLF) : log-transformed very low frequency power.

*:

p-value < 0.05 between 1st and 2nd HRV.

†:

p-value < 0.05 between 1st and 3rd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.

Table 10.

The Comparison of Norm LF between Venesection with Cupping Therapy Group and Control Group

Normalized LF 1st HRV 2nd HRV§ 3rd HRV
Venesection with cupping therapy*,, 60.78±20.37 66.90±18.47 74.13±14.54
Control 60.32±20.87 60.51±21.10 64.75±17.27

Norm LF : normalized low frequency power.

*:

p-value < 0.05 between 1st and 2nd HRV.

†:

p-value < 0.05 between 1st and 3rd HRV.

‡:

p-value < 0.05 between 2nd and 3rd HRV.

§:

p-value < 0.05 between 1st and 2nd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.

Table 11.

The Comparison of Norm HF between Venesection with Cupping Therapy Group and Control Group

Normalized HF 1st HRV 2nd HRV§ 3rd HRV
Venesection with cupping therapy*,, 39.22±20.37 33.10±18.47 25.87±14.54
Control 39.68±20.868 39.49±21.10 35.25±17.27

Norm HF : normalized high frequency power.

*:

p-value < 0.05 between 1st and 2nd HRV.

†:

p-value < 0.05 between 1st and 3rd HRV.

‡:

p-value < 0.05 between 2nd and 3rd HRV.

§:

p-value < 0.05 between 1st and 2nd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.

Table 12.

The Comparison of LF/HF Ratio between Venesection with Cupping Therapy Group and Control Group

LF / HF ratio 1st HRV 2nd HRV 3rd HRV,
Venesection with cupping therapy, 2.64±3.19 3.91±6.19 5.36±6.56
Control 2.51±2.23 2.60±2.39 2.72±2.11
†:

p-value < 0.05 between 1st and 3rd HRV.

‡:

p-value < 0.05 between 2nd and 3rd HRV.

‖:

p-value < 0.05 between 1st and 3rd HRV.

¶:

p-value < 0.05 between 2nd and 3rd HRV.