The Effects of Pharmacopuncture(Eugenia caryophyllata THUNB.) on the High Fat Diet-induced Obese ICR Mice

Sung Jin Kim; Hyun Jong Lee; Bong Hyo Lee; Yun Kyu Lee; Seong Chul Lim; Tae Young Jung; Jae Soo Kim

doi:10.13045/acupunct.2013007

J Acupunct Res > Volume 30(3); 2013 > Article

Kim, Lee, Lee, Lee, Lim, Jung, and Kim: The Effects of Pharmacopuncture(Eugenia caryophyllata Thunb.) on the High Fat Diet-induced Obese ICR Mice

Original Article

The Acupuncture 2013; 30(3): 75-85.

Published online: June 20, 2013

DOI: https://doi.org/10.13045/acupunct.2013007

The Effects of Pharmacopuncture(Eugenia caryophyllata Thunb.) on the High Fat Diet-induced Obese ICR Mice

Sung Jin Kim¹, Hyun Jong Lee¹, Bong Hyo Lee¹, Yun Kyu Lee¹, Seong Chul Lim¹, Tae Young Jung², Jae Soo Kim^1,^*

¹Department of Acupuncture & Moxibustion, Meridian & Acupoint, Colleage of Oriental Medicine, Daegu Hanny University

²Je-Han Oriental Medical Academy

^*Corresponding author : Department of Acupuncture & Moxibustion, Meridian & Acupoint, Colleage of Oriental Medicine, Daegu Hanny University, 136, Sincheondong-ro, Suseong-gu, Daegu, 706-828, Republic of Korea Tel : +82-53-770-2112 E-mail : jaice@hanmail.net

Received May 11, 2013 Revised May 29, 2013 Accepted May 29, 2013

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Abstract

Objectives :

The purpose on this study is to show the anti-obesity effect of Eugenia caryophyllata Thunb. pharmacopuncture in mice fed a high fat diet.

Methods :

Male ICR mice were divided into three groups, which were fed a normal AIN diet(N), a high fat diet(CT), a high fat diet and injected with 50 mg/kg of Eugenia caryophyllata Thum. pharmacopuncture(EC) for 8 weeks.

Results :

1. The levels of body weight gains were significantly increased in CT compared with N and decreased in EC compared with CT.

2. The levels of absolute liver weight and adipose-tissue weight were significantly decreased in EC compared with CT. The levels of relative adipose-tissue weight were significantly decreased in EC compared with CT.

3. The levels of total cholesterol(TG), triglycerid(TC), high density lipoprotein(HDL) cholesterol and low density lipoprotein(LDL) cholesterol were significantly increased in CT compared with N and decreased in EC compared with CT. The levels of HDL/LDL ratio were shown there were no significant differences in all groups.

4. The levels of adiponectin in serum were remarkably decreased in CT compared with N and significantly increased in EC compared with CT.

5. The levels of measuring adipocyte number in adipose tissue was significantly decreased in CT compared with N and increased in EC compared with CT.

Conclusions :

These results suggest that Eugenia Caryophyllata Thunb. has an anti-obesity effect in mice and that the effect is mediated by inhibition of fat gain.

Key Words: Eugenia caryophyllata Thunb.; Pharmacupuncture; Obesity.

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