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J Acupunct Res > Volume 30(3); 2013 > Article
Kwak, Kang, and Lee: The Effect of Phaseoli Semen Herbal-acupuncture at KI10 in Lipopolysaccharide Induced Acute Nephritis in Rats
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Abstract

Objectives :

This study was designed to evaluate the effects of Phaseoli Semen Herbal-acupuncture(PS-HA) at KI10 in acute nephritis induced by lipopolysaccharide(LPS) in rat.

Methods :

The rats were divided into 5 groups, which were control, LPS, PS-HA, NP and saline group. LPS, PS-HA, NP and saline groups were given LPS to induce acute nephritis and control group did not receive LPS. LPS group did not receive any treatment after the onset of acute nephritis. PS-HA, NP and saline group received PS-HA, normal acupuncture, and saline injection at KI10 three times per week, respectively. To evaluate the effect of PS-HA at KI10, the complete blood count, BUN, creatinine, TNF-α, and CINC-1 in serum were measured. To show its effect on renal function, creatinine, and total protein in urine was measured as well as urine output. The level of myeloperoxidase in renal tissue was quantified and complete histology was done in kidney samples obtained from the rats.

Results :

PS-HA group showed a significant reduction in the proportion of WBC and neutrophil, serum BUN, TNF-a, and CINC-1 compared to LPS group. Furthermore, a significant increase in urine output and a decrease in urinary creatinine level, MPO in renal tissue, and number of neutrophils at glomerulus was observed in PS-HA group compared to LPS group

Conclusions :

PS-HA at KI10 was shown to have a significantly effect on treating LPS induced acute nephrits. Therefore, future study is needed to further evaluate the clinical usefulness of PS-HA at KI10 in treating acute nephritis.

VI. References

1. Braunwakd E, Fauci A, Kasper D, Hauser S, Longo D, Jameson J. Harrison’s Principles of Internal Medicine, 15/e. Seoul: MIP. 2003:1583–89.

2. Du HK. Oriental Kidney System Internal Medicine. Seoul: Sungbosa. 2003:225–301.

3. Choi KH. Steps to Internal Medicine(5). Seoul: Jungdam. 2008:116–45.

4. Committee of Korean Textbook Publisher. Herbology. Seoul: Yeonglimsa. 2005:355–56.

5. Ahn DK. Illustrated Book of Korean Medicinal Herbs. Seoul: Kyohaksa. 2002:393.

6. Yim YK, Kim JP, Kim TH. Korean Meridian & Acupoint(Kakron). Daejeon: Obikihoek. 2006:676–8.

7. Committee of Korean Acupuncture & Moxibustion Textbook Publisher Acupuncture & Moxibustion(Sang). Paju: Jipmundang. 2008:175–6.

8. The Korean Society of Nephrology Restration Board. Renal Replacement Therapy in Korea - Insan Memorial Dialysis Registry 2004-. The Korean Journal of Nephrology. 2005;24(2):425–57.

9. National Health Insurance Service. 2008;Benefits by Frequency of Disease(2004).

10. Choi JB, Lee KH, Kim YS. Beneficial Effect of Liuwei Dihuang Tang Jia Renshen · Huangqi Extract on Cisplatin Induced Kidney Toxicity in Rats. Journal of Korean Oriental Internal Medicine. 2003;24(3):579–87.

11. Hwang YG, Jeong JC. Effect of Salviae Radix on renal tubular reabsorption in rabbits with mercury-induced acute renal failure. Journal of Korean Oriental Internal Medicine. 2000;21(2):227–34.

12. Yoon CH, Jeong JC, Shin US. Effects of Cervus elaphus Acua-Acupuncture’s solution on damage of Rat’s Kidney induced by Ischemia and Reflow. Journal of Korean Oriental Internal Medicine. 1999;20(1):111–21.

13. Kim KM, Lee H, Kang HJ, Lee YH, Yim YK. Anti-inflammatory Effect of Dianthi Semen Herbal-acupuncture at KI10 on nephritis in rats. Journal of Meridian & Acupoint. 2009;26(1):61–77.

14. Park BM, Hur B, Yim YK. Anti-inflammatory Effect of Plantaginis Semen Herbal-acupuncture at KI10 on LPS-induced nephritis in rats. Journal of Meridian & Acupoint. 2009;26(2):127–43.

15. Lee JH, Kim JH, Kim YI. Anti-inflammatory Effect of Benincasae Semen Herbal-acupuncture at KI10 on nephritis in rats. Journal of Pharmacopuncture. 2010;13(2):51–65.
crossref
16. Yoon KS, Kang JH, Lee H. Anti-inflammatory Effect on Desmodii Herba Pharmacopuncture at KI10 on Nephritis in Rats. The Journal of Korean Acupuncture & Moxibustion Society. 2011;28(3):43–54.

17. Cho E, Kang JH, Lee H. Anti-inflammatory Effect of Akebiae Lignum Parmacopuncture at KI10 on LPS-induced Acute Nephritis in Rats. The Journal of Korean Acupuncture & Moxibustion Society. 2012;29(3):41–53.

18. Cho KH, Shin SS, Lee ES, Byun BH, Byun SE, Seo BI. The Effects of Phaseoli Angularis Semen and Artemisiae Iwayomogi Herba on Biochemical and Histological Changes of Rats Fed High Fat Diet. In: The 35th International Symposium of Korean Society of Life Science; 2002;35:65.
pmc
19. Lee WT, Lee JE, Park SH, Lee KL, Park KA, Hong SG. Hole’s human anatomy & physiology. Seoul: Jungdam. 2004:821–3.

20. 27 Medical Professors Joint Translation. Textbook of Medical Physiology. Seoul: Jungdam. 2002:318–33.

21. Committee of Korean Renal Internal Medicine Textbook Publisher. Renal Internal Medicine. Seoul: Koonjachulpansa. 2011:40–45.

22. Lee MH. Immunology. Seoul: Shinilbooks. 2008:50.

23. Lee SY, Jeong YS, Kwon OH, Song KS. Clinical Laboratory Medicine. 7th ed. Seoul: Yonsei University Press. 2000:234–7, 617–9.

24. Anzai M, Maezawai R, Ohara T, Kodama K, Fukuda T, Kurasawa K. Systemic lupus erythematosus associated with facial edema. overproduction of interleukin-5. and eosinophilia. J Clin Rheumatol. 2008;14(6):361–2.
crossref pmid
25. Trowbridge HO, Emling RC. Inflammation: a review of the process. 5th Ed. Chicago: Quintessence Pub Co. 1997:219–45.

26. Cho HY, Noh KH, Cho MK, et al. Anti-oxidative and Anti-inflammatory Effects of Genistein in BALB/c Mice Injected with LPS. Journal of Korean food science and nutrition. 2008;37(9):1126–35.
crossref
27. Park SJ, Song HJ. Anti-inflammatory effect of extract of Pulsatilla koreana NAKAI. in LPS-stimulated Murine peritoneal macrophage. Korean Journal of Herbology. 2007;22(1):111–7.
crossref
28. Bae GS, Park HJ, Kim DY, et al. Inhibitory Effect of Extract of Teucrium veronicoides on the Production of Inflammatory Cytokines. Korean Journal of Herbology. 2008;23(3):119–25.

29. Beutler B, Cerami A. The biology of cachetin TNR-R primary mediator of the host response. Annu ReV Immunol. 1989;7:625–55.
crossref pmid
30. Abboud HE. Growth factors in glomerulonephritis. Kidney Int. 1993;43(1):252–67.
crossref pmid
31. Yi KN, Kwon OH. Clinical Pathology File. Third Edition. Seoul: Eui-Hak Publishing & Printing Co. 2000:95–8, 102–5, 1436–39.

32. Ha JY, Kim YK, Lee KS, Min KR, Kim YS. Inhibitory effects of herbal extracts on CINC-1 induction in LPS-stimulated rat kidney epitheloid NRK-52E cells. Natural Product Science. 1997;59–70.

33. Song KY, Ji JG, Ham EG. Core Pathology. Seoul: Korea Medical Books Pub. 1998:573–620.

34. Kim SB, Park JS, Seo JY, Kwon GB, Lee HS, Ryu DG. Effects of Semen Phaseoli Water Extract on the Renal Fuction in Rats. Journal of Oriental Physiology. 1999;14(1):123–8.

35. Sela S, Shurtz-Swirski R, Cohen-Mazor M, et al. Primed peripheral polymorphonuclear leukocyte: a culprit underlying chronic low-grade inflammation and systemic oxidative stress in chronic kidney disease. Journal of the American Society of Nephrology. 2011;30(7):603–15.
crossref


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