Original Article

Journal of Acupuncture Research 2020; 37(3): 167-172

Published online August 24, 2020

https://doi.org/10.13045/jar.2020.00185

© Korean Acupuncture & Moxibustion Medicine Society

Evaluation of the Single-Dose Toxicity of Capsaicin Pharmacopuncture in Rats

Ji Hye Hwang1, Jaseung Ku2, Chul Jung3*

1Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, Korea;2Bogwang Korean Medical Clinic, Seoul, Korea;3Namsangcheon Korean Medicine Clinic, Seoul, Korea

Received: June 18, 2020; Revised: July 9, 2020; Accepted: July 20, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: This study aimed to assess the toxicity of capsaicin (CP) pharmacopunture in an animal model. Methods: The toxicity of a single-muscular dose of CP (45.45 mg/mL) was evaluated in 6-week-old male and female Sprague-Dawley rats. A total of 20 rats were assigned to 2 groups which were sex and weight matched. All rats acclimatized for 1 week before receiving 1.0 mL of CP (45.45 mg/mL) or normal saline solution(control) intramuscularly. The general condition and mortality of the animals were observed. The rats were sacrificed 2 weeks after CP was administered and histopathology was performed. Results: No abnormal symptoms or deaths were observed, and there was no difference in body weights between the CP and control groups throughout the study. No significant differences in histopathology were observed between the groups. Conclusion: No toxicological changes related to the administration of CP were observed. This study indicated that the safe dose of CP in Sprague-Dawley rats was 1.0 mL of CP (45.45 mg/mL) or less. Further studies are needed to confirm the safety of CP in the human body.

Keywords acupuncture, capsaicin, pharmacopuncture, safety, toxicity

Article

Original Article

Journal of Acupuncture Research 2020; 37(3): 167-172

Published online August 24, 2020 https://doi.org/10.13045/jar.2020.00185

Copyright © Korean Acupuncture & Moxibustion Medicine Society.

Evaluation of the Single-Dose Toxicity of Capsaicin Pharmacopuncture in Rats

Ji Hye Hwang1, Jaseung Ku2, Chul Jung3*

1Department of Acupuncture and Moxibustion Medicine, College of Korean Medicine, Gachon University, Seongnam, Korea;2Bogwang Korean Medical Clinic, Seoul, Korea;3Namsangcheon Korean Medicine Clinic, Seoul, Korea

Received: June 18, 2020; Revised: July 9, 2020; Accepted: July 20, 2020

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background: This study aimed to assess the toxicity of capsaicin (CP) pharmacopunture in an animal model. Methods: The toxicity of a single-muscular dose of CP (45.45 mg/mL) was evaluated in 6-week-old male and female Sprague-Dawley rats. A total of 20 rats were assigned to 2 groups which were sex and weight matched. All rats acclimatized for 1 week before receiving 1.0 mL of CP (45.45 mg/mL) or normal saline solution(control) intramuscularly. The general condition and mortality of the animals were observed. The rats were sacrificed 2 weeks after CP was administered and histopathology was performed. Results: No abnormal symptoms or deaths were observed, and there was no difference in body weights between the CP and control groups throughout the study. No significant differences in histopathology were observed between the groups. Conclusion: No toxicological changes related to the administration of CP were observed. This study indicated that the safe dose of CP in Sprague-Dawley rats was 1.0 mL of CP (45.45 mg/mL) or less. Further studies are needed to confirm the safety of CP in the human body.

Keywords: acupuncture, capsaicin, pharmacopuncture, safety, toxicity

JAR
Aug 31, 2023 Vol.40 No.3, pp. 177~292

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